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Postmenopausal women taking aromatase inhibitors AIs for hormone receptor-positive breast cancer may find safe relief from adverse side effects with vaginal testosterone and estrogen preparations. Postmenopausal women are usually placed on aromatase inhibitors AIs following initial treatment of hormone receptor-positive breast cancer. These medications work by blocking the production of estrogen. While that effect is very beneficial in reducing cancer recurrence and improving survival, it may also cause vaginal dryness, painful sexual intercourse dyspareunia and decreased libido. Studies have looked into different hormone preparations that may be useful and safe for this group of women.

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Vaginal Testosterone Cream vs ESTRING for Vaginal Dryness or Decreased Libido in Early Stage Breast Cancer Patients (E-String)

Testosterone therapy in women: Does it boost sex drive? - Mayo Clinic

Serum sex steroids were measured. A total of 44 women were randomly assigned and 37 provided evaluable data, mean age At 26 weeks, the mean between-group difference in the baseline-adjusted change in FSFI satisfaction scores was significantly greater for the IVT group than the placebo group mean difference 0. Serum sex steroid levels did not change. Few women had UI symptoms, with no treatment effect. IVT significantly improved sexual satisfaction and reduced dyspareunia in postmenopausal women on AI therapy.
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NEJM Journal Watch

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